BMY Q3 '26

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   “So we're looking forward to see SSP data this year.”

   Analyst asked: Thank you for the question. This is Zach Dunn for Seamus Fernandez. Just to start, as you mentioned, there's been a series of positive phase three programs that have read out successfully. And I'm not sure these are getting fully appreciated. So what do you think the market is missing from these readouts? And then focusing on the upcoming readout for Milvexian in SSP. Can. Based on the baseline ch

   Management, 35.8x volume, adj. next 5 min: -1.86% raw vs +0.21% sector, peers +0.14%

   New, abnormal minute +2 min after the statement

   high confidence

2. 208:26 ETQ&Astock alone▲ +1.36%

   “We know that safety and tolerability will be a key area of differentiation for at Milperund.”

1. -2.84%0:00OperatorWelcome to the Bristol-Myers Squibb 3rd Quarter 2026 Earnings Conference Call. All participants will be in a listen-only mode. Should you need assistance, please signal a conference specialist by pressing the star key followed by zero. After today's presentation, there will be an opportunity to ask questions. To ask a question, you may press star, then 1 on your telephone keypad. To withdraw your question, please press star, then 2. Please note, this event is being recorded. I would now like to turn the conference over to Chuck Triano, Senior Vice President and Head of Investor Relations. Please go ahead.
2. -2.84%0:44ManagementThank you, and good morning, everyone. We appreciate you joining our 3rd Quarter 2026 Earnings Call. With me this morning with prepared remarks are Chris Berner, our Board Chair and Chief Executive Officer, and David Elkins, our Chief Financial Officer. Also participating in today's call is Adam Lienkowski, our Chief Commercialization Officer, and Chris Berner. And with me is Christian Massachasey, our Chief Medical Officer and Head of Global Drug Development. Earlier this morning, we posted our quarterly slide presentation to BMS.com that you can use to follow along with Chris and David's remarks. Before we get started, I'll remind everybody that during this call, we will make statements about the company's future plans and prospects that constitute forward-looking statements. Actual results may differ materially from those indicated by those forward-looking statements
3. -0.62%1:28Managementas a result of various important factors, including those discussed in the company's report. The company's report and the company's SEC filings. These forward-looking statements represent our estimates as of today and should not be relied upon as representing our estimates as of any future date. And we specifically disclaim any obligation to update forward-looking statements, even if our estimates change. We'll also focus our comments on our non-GAAP financial measures, which are adjusted to exclude certain specified items. Reconciliations of certain non-GAAP financial measures to the most comparable GAAP measures are available at BMS.com. Finally, unless otherwise stated, all comparisons are made from the same period in 2025 and sales growth rates will be discussed on an underlying basis,
4. -1.20%2:12Managementwhich excludes the impact of foreign exchange. All references to our P&L are on a non-GAAP basis. And with that, I'll hand it over to Chris. Thanks, Chuck. Good morning, everyone, and thank you for joining our Q3 2026 earnings call. We reported another quarter of double-digit growth in our growth portfolio and progressed our plans to the next quarter. We have plans to de-risk the pipeline to position the company for long-term success. We have seen several positive registrational readouts and regulatory approvals over the past few months, and we expect more to come, bringing the next wave of launches into sharper focus. We are executing well commercially, our differentiated pipeline is advancing nicely, and we continue to operate with discipline,
5. -1.20%2:55Managementwhich gives us strategic flexibility to invest for sustainable growth. Based on the strength of our results, we are raising our net worth of $1.5 billion per year, and we are raising our full-year guidance. David will provide additional details on this shortly. Let me start with our Q3 performance on slide 4. Our growth portfolio continues to deliver solid results, with sales increasing 12%, driven by a broad set of differentiated products. We generated strong performance in key brands, including Reblazil, Breonzi, Opdulag, Cuvantic, and Chemzios. We also continue to expand the reach of our medicines. In September, Chemzios received approval for an expanded indication and became the only FDA-approved therapy for pediatric patients with obstructive HCM.
6. -1.20%3:39ManagementWe also achieved an important milestone in the quarter with the FDA's accelerated approval of Zembexis, the first approved cell mod, and the newest addition to our portfolio. Zembexis is approved for the treatment of multiple myeloma, where the combination of a highly efficacious and convenient oral option is an important treatment advancement for patients in both community and academic settings. We are encouraged by positive early launch feedback and by the compelling Phase III data we announced earlier this month, where Zembexis demonstrated a meaningful improvement in progression-free survival. We will present these data at ASH in December. These results further strengthen our conviction in cell mods and our broader targeted protein degradation platform, where BMS is a clear leader.
7. 0.00%4:24ManagementBehind Zembexis, our second cell mod, Mezignamide, has a PDUFA date of May 13, 2027. Mezignamide offers the potential to introduce another highly efficacious and convenient oral option for a different segment of multiple myeloma patients. We also continue to advance glucotamide in lymphoma and will present the first Phase II data in frontline follicular lymphoma at ASH. The momentum in our late-stage pipeline has accelerated. In the past two months alone, we announced positive data for four registrational studies. These include Zembexis PFS, as I mentioned earlier, and Zembexis PFS, as I mentioned earlier, and Zembexis PFS. Zembexis PFS is a new type of cell mod that is being developed in the field of cell mod. Zembexis PFS is a new type of cell mod that is being developed in the field of cell mod. Zembexis PFS is a new type of cell mod that is being developed in the field of cell mod. Admilpirant in idiopathic pulmonary fibrosis, interim results for RAISE-101 in GEPNETs,
8. 0.00%5:07Managementand Arlocell in relapsed and refractory multiple myeloma. Let me comment on the last three. Admilpirant met its primary endpoint at the 60 mg dose with a favorable safety and tolerability profile that supports its potential as a first-in-class IPF treatment. IPF is a progressive and often fatal disease where there remains a need for effective, well-tolerated treatment options like Admilpirant. We will discuss the IPF results with regulators and expect Phase III results in progressive pulmonary fibrosis in the first quarter of next year. PPF is a larger opportunity in another area where Admilpirant has significant commercial potential. With respect to RAISE-101, our attenuium-based radiopharmaceutical therapy,
9. 0.00%5:51Managementwe're encouraged by the interim readouts in GEPNETs. These results demonstrated a clinically meaningful improvement in PFS in patients whose disease has progressed following existing lutetium-based therapy. These were the first Phase III results for an alpha-emitting targeted RPT, representing an important milestone for RAISE-101 and further strengthening our conviction in radiopharmaceuticals as a platform. We are engaging with the FDA on next steps towards regulatory submission. Finally, Arlocell, our GPRC-5D direct at CAR-T, delivered positive results in the Registrational Phase II Quintessential Study this September.
10. 0.00%6:30ManagementThis study represents the only prospective trial exclusively conducted in the post-BCMA, quadruple class-exposed setting a growing patient population with poor outcomes and no therapies approved specifically for this segment. As these programs advance, we are building the manufacturing foundation for the next generation of our medicines, with two U.S. investments recently announced. In Houston, we shared plans for a new state-of-the-art manufacturing campus at Generation Park, an approximately $2.3 billion investment that will create nearly 500 skilled jobs.
11. 0.00%7:11ManagementThis facility will give us manufacturing flexibility across small molecules, biologics, and antibody drug conjugates. It is also designed to evolve and scale to meet patient needs for decades to come. In Indiana, RAISE-Bio is investing more than $170 million to establish a new radiopharmaceuticals, radiopharmaceutical manufacturing facility, complementing its existing footprint in the state and creating up to 100 new jobs by the end of 2029. Together, these investments support the next wave of medicines coming through our pipeline and advance our U.S. manufacturing commitments. Turning to slide 5, as we look ahead,
12. 0.00%7:52Managementwe have several meaningful readouts over the remainder of 2026 and into 2027. Before year end, we expect Phase III data for Milvexia, and we expect Phase III data for Milvexia, and we expect Phase IV data for Milvexia, and secondary stroke prevention and SOTIC II and lupus. With COBINFI, we will share open-label Alzheimer's disease psychosis data from the ADEPT-1 and from the long-term extension ADEPT-3 studies at CTAD next month. In 2027, we continue to expect results for Milvexia and atrial fibrillation in the first quarter. We also anticipate additional data from the broader ADEPT program, Bipolar I data from the COBINFI balsam studies, and the first registrational data for GLA, glucotamide, and high-risk first-line LBCL. So while we have made good progress in our pipeline,
13. +1.23%8:37Managementthere's more to come. As we close out the year and move into 2027, we are focused on a few key priorities as noted on slide 6. First, sustaining the momentum across our growth portfolio. We now have eight growth portfolio medicines, each annualizing over $1 billion based on Q3 sales, giving us a broad base of growth drivers. Second, translating positive and negative outcomes, and then, making a pipeline progress into filings, approvals, and successful launches. Zinbexis is an early example of that progression, and as additional studies read out, our focus will be on launch preparedness and moving with urgency to bring these medicines to patients. Third, continuing to rewire how we operate. We're focused on becoming faster and more efficient in R&D,
14. +1.23%9:20Managementand over the past year, we have made changes across the organization to strengthen how we design and conduct clinical trials. At the same time, we continue to drive protocols, and we continue to drive protocols, and we continue to drive protocols, and we continue to drive protocols, including through our organizational structure, capital allocation, decision-making process, and the use of technology. That discipline gives us flexibility to invest behind the growth portfolio and pipeline, pursue business development where it makes sense, and return cash to shareholders. Taken together, we're entering the final quarter of the year with real momentum. Our growth portfolio is performing well, we're advancing our pipeline with meaningful wins, and remain highly disciplined, discipline in ensuring our cost structure is aligned with our revenue base. The team is energized
15. +1.23%10:04Managementand focused on delivering value for patients and our shareholders. With that, I'll turn it over to David. Thank you, Chris, and good morning, everyone. Our third quarter results reflect continued strong execution across our growth portfolio and continued strength from Eloquus. We remain focused on financial discipline, balancing investments, and our growth drivers with continued productivity improvements. Based on our performance year-to-date and our outlook for the remainder of the year, we are further raising our full-year guidance. Let me begin with a review of our third quarter results. Starting with slide eight, total revenue in the third quarter increased 7% year-over-year to approximately $13.1 billion. Growth portfolio revenue rose 12% to $7.7 billion, driven by
16. +1.23%10:48Managementdouble-digit growth across several products. Our legacy portfolio revenue increased 1%, with growth in Eloquus 1%. More than offsetting the declines from generic entry across the remainder of the legacy portfolio. Turning to product performance on slide nine, starting with oncology, for Updevo, revenue decreased 6% year-over-year to approximately $2.4 billion, primarily reflecting continued conversion to Guvantic in the U.S. and in Europe. Guvantic continued its strong launch trajectory with revenue of $334 million, representing sequential growth of 28%, and is now annualizing at over $1.3 billion. Updela delivered another quarter of strong double-digit growth, driven by continued global
17. +1.23%11:30Managementdemand, and its leading position as a standard of care in first-line melanoma in the U.S. Turning to slide 10, Rebozel grew 22% to $750 million, reflecting continued uptake in first-line MDS-associated anemia. Breonzi posted 48% growth, resulting in revenue of $526 million, driven by its best-in-class profile and strong demand in both the U.S. and internationally. Moving to cardiovascular and immunology on slide 11, Eloquist's revenue was approximately $4.7 billion, up 26%, driven by net price, along with strong demand and continued market share gains. Eloquist's sales in Q4 will be impacted by the upcoming LOE in Europe, which will be
18. +1.23%12:13Managementpartially offset by the continued growth in the U.S. Chemzio's revenue increased 42% to $420 million, reflecting continued strong demand growth, including new patient starts and deeper patient growth. The BAMFI revenue grew $14.9 billion, up 26%, driven by net price, along with strong demand and continued market share gains. On a sequential basis, revenue was impacted by the typical inventory drawdown during the third quarter, which we expect will normalize in the fourth quarter. Now moving to immunology. Global revenue for Sertictu grew 25%. We are supporting the recent indication for psoriatic arthritis in adults and look forward to the upcoming Phase III readouts in lupus expected by year-end. I will wrap up our product performance review on slide 12 with neuroscience. The BAMFI revenue grew $13.9 billion, up 21%. We are supporting the recent indication for psoriatic arthritis in adults and look forward to the upcoming Phase III readouts in lupus expected by year-end. We are supporting the recent indication for psoriatic arthritis in adults and look forward
19. +1.23%12:57Managementto the upcoming Phase III readouts in lupus expected by year-end. The BAMFI revenue grew 33% to $57 million in the quarter. On a sequential basis, inventory destocking offset increased demand. We anticipate that revenue will more closely track prescription volume going forward. Let's now move to the P&L on slide 13. Gross margin in third quarter was 68.4%, reflecting product mix and, to a lesser extent, a one-time expense for contract termination. Operating expenses for the third quarter were $4.1 billion. We continue to benefit from our Strategic Productivity Initiative, which is a key part of our business. It was enabling us to reduce expenses in identified areas while maintaining flexibility to invest in multiple growth-oriented opportunities. Our effective tax rate in the quarter was 14.1%, reflecting jurisdictional earnings mix and the impact of acquired and process R&D charge.
20. 0.00%13:41ManagementAnd we had a $0.58 per share impact from acquired and process R&D and licensing income in the quarter. Considering all these factors, diluted earnings per share was $1.35 for the quarter. Turning to the balance sheet and capital allocation high. As the slide 14 highlights, we remain in a solid financial position with approximately $13 billion in cash equivalents and marketable securities as of September 30th, and we generated approximately $4.2 billion in operating cash flow during the quarter. In terms of capital allocation, we maintain a strategic and balanced approach to deploying our strong cash flows. Business development remains a priority, and we are regularly evaluating opportunities in the therapeutic areas we know best while continuing to return cash to our shareholders, third-party and private sector.
21. 0.00%14:24ManagementOur commitment to the dividend is also a priority. Now moving to guidance on slide 15. We are increasing our full-year revenue guidance based upon our year-to-date results and our current projections for the balance of the year. When excluding the third quarter acquired and process R&D charges and licensing income of $0.58 per share, the midpoint of our 2026 non-GAAP EPS guidance would have increased by approximately $0.15 per share. After including the $0.58 per share previously referenced, our expected revenue increase would be $0.05 per share. Our expected non-GAAP EPS guidance range for 2026 is now $6.35 to $6.55. We are maintaining our projections for gross margin, operating expenses, and tax rate while
22. 0.00%15:06Managementslightly lowering the expense level on our other income and expense line. Incorporated into these revisions is a total legacy portfolio revenue decrease now expected to be between 3% and 5%, while we continue to expect Eloqua's full-year revenue growth of 20% to 25%. Slide 15. In closing, our strong performance year-to-date reinforces our confidence in the business. Remain focused on executing across our growth portfolio and pipeline, while maintaining financial discipline to deliver long-term value for our patients and shareholders. Slide 16. And with that, I will now turn the call back over to Chuck for Q&A. Chuck Liddell, M.D.: Betsy, could we please poll for questions?
23. 0.00%15:44OperatorBetsy Starr, M.D.: We will now begin the question and answer session. To ask a question, you may press star then 1 on your telephone keypad. Betsy Starr, M.D.: If you are using a smartphone, please press star then 1. If you are using a smartphone, please press star then 1. If you are using a speakerphone, please pick up your handset before pressing the keys. We ask that you please limit yourself to one question. To withdraw your question, please press star then 2. At this time, we will pause momentarily to assemble our roster. The first question today comes from Michael Yee with UBS.
24. 0.00%16:23AnalystPlease go ahead. Michael Yee, UBS, Thank you for the question. Congrats on the good quarter. Recently you had results for the admiral parent drug, as you just mentioned. And you mentioned that you were looking for a new drug. What are the results? Michael Yee, UBS, Thank you for the question. As you just mentioned, and there were some mixed results in the IPF study. Could you just comment a little bit about your confidence at the 120-meg high dose, which had some more mixed results, and whether you still expect that dose to be working and that you still have high confidence in 60 and 120 in the PPF study to complete the package? Thank you.
25. 0.00%16:56ManagementMichael Yee, UBS, Thanks for the question, Mike. Christian? Christian Bauer, UBS, Good morning, Mike. Thank you for the questions. First of all, let me... Michael Yee, UBS, Thank you. Christian Bauer, UBS, Thank you. Christian Bauer, UBS, Thank you. Michael Yee, UBS, Thank you. Michael Yee, UBS, Thank you. Christian Bauer, UBS, Thank you. Let me tell you, I'm pleased with the positive top-line results for the phase three aloft IPF study. We believe, I believe that this drug has the potential to be the first-in-class LPA1 antagonist. You know, in a setting like pulmonary fibrosis, it's very difficult to treat, and honestly, a very challenging drug development area. And as we announced, the trial... The trial met the primary point at 60 milligram, with statistically significant improvement in FVC.
26. 0.00%17:40ManagementIn addition, we have seen an excellent safety and tolerability profile. This is both with 60 milligram BID and 100 milligram BID. For instance, the number of discontinuation for a diverse event were lower, or the same level of placebo. 120, going to your question. We have seen an improvement. A decline. We see, but not statistically significant. Our preclinical work demonstrated an adequate target coverage with both doses, 60 and 120. But you may recall that we did not formally test 120 milligram in phase two setting clinically. It was a modeling.
27. 0.00%18:23ManagementAnd we had a run-in in the phase three study. So we continue to analyze the data. We continue to dig into the data. We will present the data in medical... Medical meeting next year. Anyway, we are pleased with this outcome. We will discuss these results with health authorities. And we are looking forward to the outcome of PPF study happening next year. You know, we cannot predict what will be the outcome according to the doses. But we are testing both of them. And we will see the outcome. Thanks, Christian. Next question, please, operator.
28. 0.00%18:58OperatorThe next question comes from Alex Hammond with Wolf Research. Please go ahead.
29. -0.26%19:04AnalystThanks for taking the question. Since that burden line was approved in August and Medleys approved all is expected kind of mid-year next year, what are you seeing on the ground in the early weeks of launch? And what feedback are you hearing from the community and academic myeloma physicians on uptake, tolerability, and where they're using it? Thank you.
30. -0.26%19:23ManagementThanks for the question, Alex. Adam? So, Alex, we are excited to have launched Symbexis. It's the first approved cell mod in the market. Now, it's still early in the launch, but our teams are executing well. We're pleased with the adoption. We're seeing over the first few weeks on the market. And physician feedback has been positive, largely based on the strength of the MRD results as well as the simplicity of use. We're seeing use come from both the community and the hospital setting. We do expect the majority of use to come from the community where 70 to 80 percent of patients are treated. So we'll see that longer term. Our teams are focused on establishing a broad base of prescribers and reinforcing the efficacy, the safety,
31. -0.26%20:05Managementand quite frankly, the simplicity of using Symbexis to replace Revlimid and Pomelis-based regimens. We also are excited about the PFS data, which will further augment the efficacy profile. And we look forward to presenting these data at ASH. So we're seeing good commercial potential for Symbexis. And for Mazignamide, we're excited to launch it as well and aim for both products to be foundational therapies in the community by replacing IMIDS over time. Thanks, Adam. Let's take our next question.
32. -0.26%20:35OperatorThe next question comes from Seamus Fernandez with Guggenheim. Please go ahead.
33. -0.26%20:41AnalystThank you for the question. This is Zach Dunn for Seamus Fernandez. Just to start, as you mentioned, there's been a series of positive phase three programs that have read out successfully. And I'm not sure these are getting fully appreciated. So what do you think the market is missing from these readouts? And then focusing on the upcoming readout for Milvexian in SSP. Can. Based on the baseline characteristics and assuming the ass indexing time from index event data are reliable, how confident are you that SSP can still be successful? I know we and a lot we have talked to have looked at those forest plots from oceanic stroke. So any color you can provide there would be helpful. Thank you.
34. -2.07%21:27ManagementThanks for the question, Ben. Maybe on the Milvexian question, Christian, you could start and then I'll close out with just your comments on the market. You you Seamus started with the redoubts. Let me let me let me go there first. We are pleased I'm pleased to see that this 2026, we are getting a very good pace, a very good flow. Last year when we started and we discussed that, we explained how much scrutiny we put in every single in every single trial. To try and find a solution. To try and find a solution. To try and find a solution. To try and find a solution. To try and find a solution. to mitigate risks intrinsically every trial may have. And I think this is starting to pay off.
35. -2.07%22:11ManagementAnd what I'm pleased is that we have positive outcomes across therapeutic areas, in hematology, in immunology, in we will have cell therapy. So this looks good. And if we close this year, because there are three domains in this year, SSP and the two SOTIC2 studies in lupus, with positive outcome, I think we can be very pleased on the rate of success that we will score in 2026. Your specific question, SSP, I think I would put in the big picture first. This study was designed based on a very solid phase two trial that we ran showing 30% risk reduction in strokes,
36. -2.07%22:56Managementand with a very careful selection of the dose and the benefit. And the benefit risk profile, efficacy, safety. I imagine you refer to the randomization window, that there are maybe different, we'll compare some competitive studies. We based all the criteria when the patient randomized based on our own phase two and based on prior phase three studies. And what I can tell you that the data are pointing that the randomization window that we selected can provide, could provide the best efficiency. So we're looking forward to see SSP data this year.
37. -2.07%23:36ManagementAnd of course, we are also very eager to see the AFIB read out Q1 next year. Ben, the only thing I would just add on top of what Christian just said is in our discussions with investors, we have been very focused on emphasizing that the long term growth that we have, the long term focus that we have is building a strong company that can deliver sustained growth, particularly as we get into the next year. Ben, I think you're right. Thank you. And I think that's what we're looking forward to seeing in the next decade. To do that, we think we've got to continue to do, frankly, what we've demonstrated this year, which is drive the business that exists today. You see that in our quarterly postings. Deliver on our late stage pipeline. Christian and team have done a really nice job of scrutinizing those studies.
38. -0.66%24:19ManagementWe're obviously happy with the results that we've seen with Arlo Sells and Bexis at Milperund and RAISE 101. We're looking forward to the additional readouts we have through the rest of this year and into next year. And as we discussed in our prepared remarks, being very disciplined in how we operate from a financial standpoint and executing consistently. We're obviously happy with the performance we've seen thus far, but the team is heads down and making sure we continue to deliver across each of those areas going forward. Thanks, Chris. Betsy, let's move to the next question, please.
39. -0.66%24:51OperatorThe next question comes from Akash Tiwari with Jefferies. Please go ahead. Hey, thanks so much.
40. -0.66%24:58AnalystCan you frame the at Milperund opportunity? Relative to some of the historical products in the space and also maybe investor expectations around Milvex or Kubenfi, we're seeing Jaxed have one of the best launches in IPF despite a modest FEC and PPF could be a bigger opportunity than IPF. So could this actually be one of your biggest products now that you have the IPF data? And did at Milperund show a benefit on time to event or mortality in your IPF trial? Thank you. Adam, do you want to take that one? Sure. I'll take that and then Chris, you can chime in.
41. -0.47%25:31ManagementYeah, Akash, thanks for the question. So we think there's significant need that remains for new and improved disease modifying therapies in both IPF and PPF that are both effective and well tolerated. And that includes impacting how patients feel. It includes how patients function and ultimately the impact on survival rates. As you know, there's a dismal survival rate in both IPF and PPF. Now, we hear from KOLs that taking a holistic approach to the data is a good idea. And that includes, as you mentioned, looking at both the primary and the secondary endpoints of the study. We know that safety and tolerability will be a key area of differentiation for at Milperund.
42. +1.36%26:13ManagementEven with the advent of newer therapies, GI tolerability and cough, they are challenging to manage, especially in an older comorbid patient population. And Christian talked about the ALOFT study showed a positive impact on FPC. But also at Milperund demonstrated a well tolerated safety profile where discontinuations due to adverse events were similar to placebo. So there's a real opportunity to gain share as effective and well tolerated treatments like at Milperund come to market. We also expect the market to grow significantly. I talked about this previously where today it's a $4 billion market. We think this market could nearly double as we're going to start to see the creation of a large, large market that will be able to support the development of new and improved disease. And that's what we're looking at.
43. +1.36%26:57ManagementWe're looking at the creation of a large second line switch and our add on market with newer treatments available. We've got a number of prelaunch activities underway with a focus on bringing in pulmonology expertise to the company, providing education to physicians on this new and promising mechanism. And we're also looking forward to the PPF readout early next year because that is the larger commercial opportunity that can complement the IPF results. Thanks, that's an amazing dad question. So, Nakashi, your question is, is more related to key secondary points, some key secondary point outcomes. We didn't disclose this. We mentioned, we took a press release about the primary and some of the safety profile.
44. +1.36%27:38ManagementI can tell you that we are pleased with the overall outcome of the trial and we will present this data in a medical meeting next year. Thanks, Christian. Let's move to our next question, please.
45. +1.36%27:50OperatorThe next question comes from Matt Phipps with William Blair. Please go ahead.
46. +1.36%27:55AnalystHi, this is Eric Thon from Michigan. I'm a senior consultant at McPhipps. Just a question on the ADEPT trials. So, with ADEPT timelines reiterated for 2027 again, I was wondering if you could give some specifics on current enrollment progress as well as site quality remediation. And if we should expect the ADEPT 1, 2, and 4 readouts to land together or be more staggered throughout the year.
47. +0.81%28:24ManagementThanks for the question. Christian, do you want to take that? Thank you, Matt, for the question. I'll start actually with the program status as you were asking for. Everything is tracking as we guided. We have a potential interim analysis for ADEPT 1 later this year. And we anticipate the top line results, readouts for all the ADEPT program throughout 2027. Some readouts can coincide or can be more or less the same time or can be staggered the year. You know, ADEPT 1 is event driven, for instance.
48. -0.36%29:03ManagementWe, I think Chris mentioned in his opening remarks, we also expect on top of ADEPT program the readouts of our bipolar 1 program in 2027. So, very important year for CoBEMF in terms of data flow. I want to point out one aspect that is important to your attention. In November, we look forward to the CTAD presentation in Boston. We are looking forward to it. Thank you. And there we will present two datasets. The first is the open label leading period from the ongoing ADEPT 1 study. And the second dataset is from the open label extension rollover study, ADEPT 3.
49. -0.36%29:44ManagementSo, both course, substantial number of patients, all patients treated with CoBEMF. This presentation will address some improvements in psychotic symptoms with CAR XT. And of course, we're waiting for the randomized control studies studies to read out, but I think the CETA data are encouraging in our view and support, I believe, support the ongoing development programs. Thanks, Rishi. Great. Let's move to our next question, please.
50. -0.54%30:10OperatorThe next question comes from Carter Gould with Cantor. Please go ahead.
51. -0.54%30:16AnalystGood morning. Thanks for taking the question. You've got a number of small cell lung cancer studies expected to read out over 27 and 28. I was hoping you could talk about your confidence and the relevancy of these studies in light of the MDELTRA frontline data and if that augurs any sort of changes to your strategy. Thank you. Christian?
52. -0.54%30:36ManagementThank you. Thank you for the good question. The data we have seen at ESMO are quite impressive, and actually we welcome this data in such a difficult disease like a standard disease. It's a small cell lung cancer. As you said, we have ongoing registrational studies with Atigo and combination of any volume and standard chemotherapy. The study is completed. We are just now looking at the readout, and we are running the combination with Pumitam and standard chemotherapy. We don't know, of course, the outcome of the study and how they can benchmark, but I think
53. -0.54%31:21Managementthese are... These are studies that allow us, first of all, to benchmark the activity of a novel mechanism of action like Atigo in this space, but targeting an important antigen expressed in most of the patients with tumors, with small cell lung cancer tumors, but also for our PD-1BGF, this will give us a benchmark because then we will prepare the next step. As you know, we started the combination with Pumitamig+. We have a GGL3 engager from Barrington, England that we announced. So we are paving the road with the next wave because we believe our asset can play in this
54. -0.54%32:05Managementspace, of course, through combinations with engagers. I think the only thing I would add is just that as you look at impressive data, and I would agree these are impressive data, over time in all of these hard-to-treat diseases, with a small cell being one of them, what's likely to occur is you're going to see, again, patients continue to be subtyped and additional therapies be required to treat patients not only in initial lines of therapy but subsequent lines of therapy. I think at the end of the day, there's going to be room for multiple agents to be engaged to help treat these patients. Thanks, Chris. Let's take our next question, please.
55. -0.54%32:43OperatorThe next question comes from Courtney Breen with Berenstain. Please go ahead.
56. -0.54%32:51AnalystHi, Bristol team. Thank you so much for taking our question today. I just wanted to zoom in to male vaccine. I think it's a very important issue. I think it's a very important issue. I think it's really important for a product to be able to meet the vaccine expectations in terms of the atrial fibrillation readout. Can you help us understand with regards to the Q1 release that we're expecting, are we likely to see the details, any miracle details in that press release, or are we just going to get a positive or not positive trial detailed here? We're trying to figure out how long do we need to wait throughout next year to actually get validation on the likely utilization of this product? product, given that that non-inferiority number on the primary endpoint is going to be so critical, and there's a wide range that can meet a successful trial. Thank you.
57. 0.00%33:34ManagementThanks for the question, Courtney. First of all, we understand that the AFib study is an important opportunity. It's an important opportunity for us. There's obviously a lot of focus. Of course, I would be remiss not to remind everyone that we need to put this study in the context of a much broader and very rich pipeline that we've got. Having said that, we get how important this readout is. In terms of how we're going to communicate in our initial press release, look, we're going to work to give an accurate view of the outcome of the study and a view that allows you to get a sense of the opportunity that we have with AFib. We understand that in that context, providing more specifics in the press release will likely be important,
58. 0.00%34:16Managementbut we're going to need to balance this, of course, with ensuring that we can communicate the data in a more fulsome way at a future medical conference. So, what I can tell you, is that we're going to be working with our partner on this program to strike that balance. Thanks, Chris. Let's take our next question, please.
59. 0.00%34:35OperatorThe next question comes from Chris Schott with J.P. Morgan. Please go ahead.
60. 0.00%34:40AnalystGreat. Thanks so much. Just one follow-up for an earlier question, and then a second one. On commercial value or your existing data set here, be enough. And then just kind of the core question I had was just, as we think about 2027, just any initial pushes and pulls we need to think about in terms of the development of the business, and maybe just extending that a little bit longer term, do you think there's anything the street's kind of getting wrong in terms of LOE cycle? Just think about kind of work consensus is currently. Thanks so much.
61. +0.75%35:23ManagementThanks for the question, Chris. Christian, do you want to start? Let me start. First of all, the study that we run, as you know, has an equal distribution of monotherapy and add-on treatments. Right. Right. Okay. Look guys, thank you very much. Thanks. Thank you. Thanks. Thank you. comment on the outcome on subgroups. You will see when we will present the data. Adam, do you want to add anything? No, I agree. I agree, Christian. That's why I talked, Chris, about the increasing and expanding size of the market because prior to the launch of this next wave of innovation in both IPF and PPF, there was very little add-on and switch use because of the high rates of mortality. In fact, 50% of patients in this disease, they do not
62. +1.44%36:07Managementsurvive five years. And also, there's a very high level of discontinuation. Half the patients discontinue treatment within 12 months. And so, the creation of a very large second line switch and or add-on market after the use of generic Alfev and Espriate will become a much more significant opportunity for these newer treatment options. So, as I said, we look forward to the PPF readout. It's a larger commercial opportunity and ultimately will complement the positive IPF results. David, do you want to comment on the 27 question? Yeah, thanks. And Chris, thanks for the question. Look, we feel
63. +1.44%36:49Managementreally good about how the business is performing this year. And I think the three quarters of beat and the momentum that we have as we exit 26 going into 27, that growth portfolio is really performing well. And as we talked about earlier, having eight products that are now annualizing over $1 billion. And that growth portfolio really shows the diversity of that. Not to mention the phase three trials that we've been talking about today coming out. Looking forward to adding those to the portfolio as we head into next year. And then, I would say, on the other side, as we already talked about with Eloquist, we anticipate that $1.5 to $2 billion step down in 27. And lastly, our
64. +1.44%37:31Managementstrategic productivity initiative, that $2 billion worth of efficiencies that we're well on track to achieve. And I think that's going to be a big part of the growth portfolio. And then, as we look at, you know, from a cash flow perspective, continue to have strong cash flow generation. You know, we ended with $13 billion of cash on hand, which gives us further strategic flexibility as we think about the portfolio. So, feeling really good about the execution this year and that continuing as we go into 27. And Chris, the only thing I would add is just that, you know, we've been consistent in saying what we're focused on and executing against that. As we think about the business today, we feel good about the momentum we have going into Q4. We hope that and anticipate that will continue into 2027. We've got some wind at our back with respect to
65. +0.75%38:15Managementlate-stage development, but clearly there's a lot of focus we have as a company on strengthening R&D and continuing to deliver, not just on that late-stage pipeline, but also progress the earlier pipeline so that we drive sustained growth over time. And then, of course, we're going to be aligning our OPEX space, as David just alluded to, to the opportunity that sets in front of us while also investing in growth opportunities. We've been really disciplined about doing those things throughout the course of this year, and that's what we're going to stay focused on. Thanks, Chris. Betsy,
66. +0.75%38:45Operatorlet's move to the next question, please. The next question comes from Asad Haider with Goldman Sachs. Please go ahead.
67. +0.75%38:53AnalystGreat. Thanks for taking the questions and congrats on all the progress. A couple of big picture questions for Chris. First, just on BD, given this remains a top capital allocation priority, would be curious to hear any updated thoughts on how you're thinking about ideal states, and how you're thinking about the future of the capital allocation. I think we're going to be looking at the next stage of development, therapeutic area, deal structures, and even transformative deals. And then, second, just would also be interested in hearing any updated framing on your efforts to embed AI across the research organization. Know that you have partnerships with both Anthropic and NVIDIA. On the Anthropic announcement earlier this week, they said that they are looking to accelerate drug development with Claude. Bristol was named as one of six partners in that effort. So what can you tell us about the progress you're seeing across the organization with these partnerships?
68. +0.75%39:37AnalystWell, I think we're going to be looking at the next stage of development, particularly as it relates to any quantifiable metrics or KPIs that your teams are reporting back to you. Thank you.
69. +0.75%39:45ManagementThanks, Asad. Maybe I'll start, and then Christian can chime in with the AI question, specific to R&D anyway. Let me start on the BD question. BD continues, as we said consistently, to be a top allocation priority. We've got a very strong late-stage pipeline, but we're always going to be looking for opportunities to source innovation, externally, if it makes sense for us to do so. And the criteria that we're going to continue to use as to how we do that is we're going to be looking for things that, opportunities that make sense for us from a scientific standpoint. They've got to fit and align with us strategically. Clearly, if there are opportunities for us to strengthen the nearer-term growth portfolio, we're going to be keenly interested in looking at
70. -0.05%40:29Managementthose. And ultimately, across all of these deals, they have to make financial sense. In terms of strategic opportunities, we're going to be looking at the size. We continue to be agnostic on the size of the deal. Far more critical to us is, does it make sense for us to be the rightful owner of the opportunity? Does it make strategic sense, and can we show value to our shareholders? And then in respect to therapeutic areas, again, these are going to be, we're going to focus mainly on those areas where we know well in therapeutic areas that make sense for us. Just maybe before I turn it over to Christian, let me comment briefly on AI investments. Look, AI, as we've said on previous calls, is an important area in investments for us. We are focused
71. -0.87%41:13Managementreally on thinking about how we can embed AI where it makes sense across the entire value chain of the company, everything from early-stage discovery through commercialization, manufacturing, and virtually all of our enabling functions. And the way we think about that is setting very specific targets that ultimately can be incorporated into operational plans. We talked previously about the fact that we put forward a 20-30% reduction in drug testing timelines, cutting in half the time from drug target selection to lead molecule identification. Those are just two examples. So while we're making AI tools broadly available at the enterprise level, we're also working towards targeted investments where we can articulate
72. -0.87%41:57Managementan ROI. And as it relates to Anthropic specifically, I think that agreement fits broadly into that strategy. But Christian, do you want to comment specifically on R&D? Sure, Chris. Let me start telling that through AI, we are accelerating actually our research and development projects. This is now a concrete fact that we can start to measure. You need to break down your research and development drug journey because there doesn't exist one solution that can solve everything. So there are specific solutions that are more focusing on research, either from early development
73. -0.87%42:41Managementand then late development projects. I think in research and discovery, AI can impact the quality but also the speed of how you develop drug candidates and how you bring fundamentally new R&D to the organization. This is very tangible. We have multiple examples that we are now having in place. In development, AI can be helpful in increasing your efficiency in terms of optimizing cost, having a pace in the way you run your projects. And then there is a second aspect that is increasing your probability of technical success. And this is something
74. -0.20%43:25Managementthat we are integrating more and more in the way of working. Just the announcement two days ago with Tempos Pathos is an example of it because we will put together data, large data set in neuroscience and we will work to have models that can help us to predict outcome. So it's a concrete thing that is happening and is helping in delivering our beautiful portfolio of drugs that, of course, require pace. David, do you want to comment on that? Thanks for your question on BD. We are actively evaluating multiple opportunities across varying deal structures, partnerships, licensing and where appropriate acquisitions. So our
75. -0.20%44:07Managementnorth star on this is about strong sustainable growth late into the decade. That's what we remain focused on. We are going to be financially disciplined around this approach but also strategic aligned. As we have done in the past, it's going to be in the therapeutic areas that we have the scientific capabilities but as well as the strategic capabilities as well as the commercial strength to maximize the value of that. So we remain very active and we are going to stay focused and financially disciplined. Thanks, David. Great. Let's move to the next question, please, Betsy.
76. -0.20%44:37OperatorThe next question comes from Mohit Bansal with Wells Fargo. Please go ahead. Great. Thank you very much for taking my question.
77. -0.20%44:45AnalystI want to turn attention to Coben Pai, if I may. So it does look like this quarter you saw 30% year-over-year growth but the numbers still appear modest relative to what we were all thinking about, how big this asset could be. So maybe this is a question for Adam. What are you seeing as the largest constraint here? Is it the identification of patients or physician willingness to prescribe, tolerability, what exactly is going on? And how do you think Alzheimer's may be different than what you're seeing in sexophilia? Thank you. Thanks for the question, Adam. Yeah, Mohit,
78. -0.15%45:21Managementthanks for the question. So we expect Coben Pai to deliver continued growth in schizophrenia with significant upside potential from future label expansions. In the quarter, you're right, we saw 30% growth year-over-year, but we also saw quarter-on-quarter a roughly 3-4% growth in total prescription volume, but net sales were impacted by an inventory decrease, which followed an inventory build in Q2, like we see with many products in our portfolio. We expect that this will normalize in Q4, and as such, the growth will continue to track along with the TRX increase that we expect to see. Now, we're seeing several positive leading
79. 0.00%46:05Managementindicators for the brand. We're driving consistent increases in new prescribers, with the number of prescribers doubling from last year. We've established differentiation across negative and cognitive symptoms of schizophrenia. However, we have clear areas where we need to make further progress. We need to accelerate new patient starts. We need to improve repeat prescribing. I think one of the bigger challenges that we've seen is we've been educating physicians on the importance of rapidly titrating Coben Pai to the effective dose of 125 mg. In order to do that, that's the way physicians will maximize efficacy. They can use anti-emetics when needed to help minimize nausea and vomiting, which occurs within the first few weeks of initiation. There's still far too
80. 0.00%46:49Managementmany patients that we see remaining on the 50 or 100 mg dose. When patients are on an effective dose and the GI toxicity is managed appropriately, we have truly seen remarkable results for this product. Now, as a result, as it pertains to Alzheimer's disease, as you know, this is a much larger market. Roughly 7 million people diagnosed with Alzheimer's disease in the U.S. 30 to 50% of patients have severe Alzheimer's disease. They also have psychosis, whether that's hallucinations or delusions or agitation. They also have, virtually all patients, have cognitive impairment. And so this is a fundamentally different market than schizophrenia. There are no approved treatments today in ADP.
81. 0.00%47:31ManagementAlzheimer's patients with psychosis have been treated off-label for many years with D2s. And unlike schizophrenia, what you see is PCPs and nurse practitioners are responsible for treating the majority of patients, with 50% of patients treated in a long-term care facility. And why is that important? Well, in addition, antipsychotics have significant safety limitations. They carry box warnings that are specific to elderly patients with dementia. And we know that D2s are associated with long-term side effects, like sedation, cognitive impairment, and movement disorders that are significant issues for long-term care facilities, where they need to
82. 0.00%48:15Managementcarefully monitor off-label utilization of antipsychotics. So, safety becomes increasingly important in the elderly patient population. And we know CoBENF is not associated with those adverse events, doesn't carry a box warning. But that said, we will take the learnings from schizophrenia and we're going to need to set appropriate expectations with patients and physicians, build confidence around managing the nausea and vomiting and the symptoms, and then we'll be ready to take the learnings. So, we're going to be working with CoBENF, but CoBENF would be the first product approved for ADP, and we believe has the potential to play a really important
83. 0.00%48:51Operatorrole in treating these patients over time. Great. Thanks, Adam. Let's go to our next question, please. The next question comes from David Amsellem
84. 0.00%48:59Analystwith Piper Sandler. Please go ahead. Hey, thanks. So, another Phase 3 readout you had recently was RAISED101, and with that it's a little bit of a stretch for me. But maybe talk through just the path forward from a regulatory perspective, and also contextualize the market opportunity here, the addressable patient population, both
85. 0.00%49:19ManagementU.S. and ex-U.S., and are you thinking about peak sales potential? Thank you. Thanks for the question. Maybe start with Christian and then Adam. Thank you, David, for the question. We're truly excited about these readouts because, as Chris was mentioning earlier, the first is the first. There are three reasons. The first is alpha actinium-based radioligands are working, post-lutetium, and potentially can work instead of lutetium. This is the first take-home message for me. The second is BMS is the first with this novel modality. And the third is the confidence in the platform because these readouts in GAPNet are very important,
86. -0.73%50:03Managementbut as you know, raised bio is a very important IND engine for our organization. We have programs in, we have a backup molecule in this space, a better molecule, and we have programs in liver cancer, GPC3, and in prostate cancer, ACP3, a novel target. And there are a few others of course that are coming up. So this is an important outcome that we'll be presenting in terms of the phase three readout next year. And of course the team started interacting with our authorities. Adam? Yes, so just to add on to
87. -0.73%50:47Managementwhat Christian said, we're pleased with the positive data readout of REES 101. This will be the first product launched from our radiopharmaceutical platform. So positive PFS interim data in SSTR2 positive GAPNets does validate our highly potent actinium based approach. Just remember GAPNets are rare tumors. We estimate the incidence of GAPNets at approximately 18,000 patients diagnosed annually in the United States. When you look at patients who are progressing from Lutathera, it's roughly 70% of patients will go on to need a subsequent therapy. And so while there are no approved treatments today, our focus will be on establishing
88. -0.73%51:31ManagementREES 101 as the clear standard of care after Lutathera. Commercially, it's a relative modest opportunity. However, bigger picture, we see REES Bio as a true IND engine with multiple INDs expected in the next five years. It will ultimately enhance our oncology portfolio with a unique platform and pipeline. Thanks Adam and Christian. Betsy, let's move to the next question please.
89. -0.73%51:55OperatorThe next question comes from Jeff Meacham with Citibank. Please go ahead.
90. -0.73%51:59AnalystAll right. Morning everyone. Thanks for the question. I was curious of the pace of conversion to CUBANTEC. Maybe just help us with how far along that transition is today. And then strategically, how much of a priority is that relative to say, Pomidamig or the REES Bio program? I'm just trying to think of how you guys view the oncology franchise for you over the longer term in the mix there. Thank you. Thanks for the question, Jeff.
91. +0.35%52:27ManagementMaybe Adam, you start with the oncology franchise. I'm just trying to think of how you guys view the oncology franchise for you over the longer term in the mix there. Thank you. Thanks for the question, Jeff. Maybe Adam, you start with the CUBANTEC and then I can kind of chime in on the second part of that question. Sure. Thanks, Jeff. We're pleased with CUBANTEC performance. The team continues to deliver strong commercial performance and execution. Jeff, we've now converted roughly 17% of IV to sub-Q, launched to date. We're seeing increasing use across multiple tumors with uptake in our monotherapy indications as well as in combination. And we routinely hear feedback from the community, specifically that CUBANTEC improves practice efficiency with a three-minute in-office subcutaneous injection. And patients prefer CUBANTEC
92. +0.35%53:09Managementwhen offered the opportunity for this formulation and truly novel technology. So we're tracking well against our expectation that physicians will convert at least 30 to 40% of our IV business to CUBANTEC. We're tracking towards the higher end of that range. And we're pleased with the CUBANTEC performance and what this means for patients and physicians. And look, the way we think about oncology treatments generally is that we're going to be looking for opportunities to, first of all, bring differentiated platforms and products to market to help patients across multiple tumors and different lines of therapy, as we talked about to the previous question on small cell. And what I'm excited about as to where
93. +0.35%53:53Managementthe pipeline is going is what you see playing out is that we've got very exciting platforms that are beginning to produce meaningful medicines. You see that in our CAR-T program, which continues to perform very well. We're very excited about subsequent opportunities that we have there with products like ArloCell. You see that in the CellMod program with Iber and Mezzi. And of course, we're also looking at the CUBANTEC platform, which is a platform that's going to continue to produce new INDs as well as new products. We've referenced in the prepared remarks, scocodamide. The RAISE 101, as you just heard,
94. +0.35%54:35Managementis the first of what we believe is going to be an important radiopharmaceutical platform. And then if you go beyond platforms and just look at potentially differentiated assets, you've got products like PUMI, which you reference. I would be remiss to not mention Isobran, which showed very good data at ESMO. So we have a number of products there. And we would put CUBANTEC into that context. CUBANTEC is an important new medicine for patients that improves upon the existing therapies that we have, notably Opdivo in immuno-oncology. So we've got a nice pipeline of differentiated products and platforms, and we're excited to continue to bring those forward and help a lot of patients across tumors.
95. +0.78%55:19ManagementThanks, Chris. Next question, please, operator.
96. +0.78%55:23OperatorThe next question comes from Truong Hien with RBC. Please
97. +0.78%55:27Analystgo ahead. Hi, guys. Thanks for squeezing me in. So you recently disclosed a patient in your Phase 1 autoimmune CAR-T trial died of sepsis pneumonia after zolacell infusion. You said it's unrelated to the June pause, but the patient had a late onset of non-ICANN motor symptoms. Can you perhaps walk us through your updated thoughts on the path forward for zolacell in autoimmune and the risk-reward for CAR-T in autoimmune?
98. +0.78%55:57ManagementThanks very much. Thanks for the question. Chris, do you want to start? Sure. Thanks, Truong, for the question. Let me start telling you that we truly remain excited about the zolacell program because when we look at the totality of our data, we had 190 patients treated in Phase 1. The overall safety and efficacy profile of this product is truly compelling. Zolacell provided meaningful benefit to patients that have severe autoimmune disorders, some of them with organ damage already, and many of these patients remain off disease-modifying therapies. So the potential is
99. +1.15%56:39Managementall there. As we said, we implemented a voluntary pause to review clinical data across the program. This is the reason why the program is paused currently. But after an extensive analysis of all our data, we identified that the root cause was a change that we made in the selection and activation of the reagent. We have now made the proper adjustment of it, and we are working with the authorities to restart the clinical program as soon as possible. Going to your question on the Grade 5, that was one fatal, unfortunately, one fatal case of second pneumonia, is the only Grade 5 event across all Zolacell programs out of 190 patients.
100. +0.06%57:23ManagementSo we are fully committed with all our expertise in cell therapy to bring this product, this CAR-T, in autoimmune diseases. Hey, Trung, maybe let me make one additional comment on Zolacell. Look, I have the distinction of having been in cell therapy before we thought it would work in hematology, but I have to remind you that this is a very important and important field. And I think it's important to remind autoimmune diseases like late-line lupus or MS. And remember, the patients that we're enrolling in these studies are patients with very severe, debilitating, and in many cases, life-threatening disease. And our goal here is to achieve immune reset and hopefully, by doing so, enable long-term
101. +0.06%58:07Managementdurable remissions. When you're doing drug development, as Christian alluded to, you're not just doing the benefit-risk profile. But the way you do that is the way we've done it, which is to be very rigorous in setting up a strong DMC, working with the best investigators in the field, and engaging transparently with regulators. And what I will tell you with Zolacell specifically is we are seeing potentially transformational activity. We're excited to continue this program. So what we're going to do is continue to be rigorous in how we conduct the study, be transparent with the broader community. And I'll tell you, our investigators and we are excited to see the potential of this product in this modality. Thanks, Chris. Operator, let's take our last question and then Chris will give a quick wrap-up.
102. +0.06%58:51OperatorThe last question today comes from Evan Siegerman with BMO Capital Markets. Please go ahead. Hi, guys. Thank you so much
103. +0.06%58:59Analystfor taking my question. I want to ask the BD1 slightly differently. You know, there's been a bit of a disconnect in the amount that you've spent in BD over the past 12 months versus some of your peers. But is this difference primarily reflect valuation discipline, confidence in your internal pipeline, or your ability to grow the growth portfolio to fill the LOE gap? Any color would be great. Thank you so much. Sure. Thanks for the
104. +0.06%59:21Managementquestion, Evan. Well, first of all, let me reiterate what I said before, which is that BD continues to be a top allocation, capital allocation priority. I think David provided a nice view of how we think about the types of deals that we have and will continue to be looking at. We're certainly not waiting for a deal that's going to be a top allocation for anything. If there's an opportunity that makes sense financially for us, can improve our ability to deliver sustained growth, we have the capacity to be in the mix. And what I would say is we continue to be very active in the space. And if a deal we think makes sense for us, we're going to be engaged. That's been the approach we've taken over the last
105. +0.36%60:03Managementnumber of years, and that's going to continue to be our focus going forward. So with that, I want to just say a big thank you to everyone for joining the call today. I know today in particular is a busy day. Let me just say in closing that we are delivering strong performance from an increasingly diversified growth portfolio. As you've seen over the last few months, our pipeline is coming into focus and beginning to translate into new launches. And importantly, we continue to be operating with financial discipline. As we continue to execute, we're well positioned to deliver long-term, durable growth into the next decade. But of course, none of this happens by accident. So I want to give a very sincere thank you to my colleagues around the world
106. +0.36%60:47Managementfor their continued focus and commitment on the mission that we have to serve the patients who need our medicine. So thank you all for joining us today. And as always, the team's available for follow-ups.
107. +0.36%60:59OperatorThe conference is now concluded. Thank you for attending today's presentation. You may now disconnect.